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As per recent studies, the translation of the mRNAs of seleno-GPxs having low priority for selenium utilization (like GPx1) is not favored under low intracellular selenium status due to the interaction of a selenium responsive negative regulator such as eukaryotic initiation factor 4a3 (eIF4a3) with their 3-UTR (Fig

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In the case of Se deficiency, Se-P will decrease first

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