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Furthermore, investigating the relative degree of tumor dependency on exogenous glutamine at distinct stages of tumorigenesisthat is, in the primary tumor initiation and expansion, local tissue invasion, survival in the circulation and seeding, and colonization of distant organsmay provide further insights into the therapeutic potential of targeting glutamine metabolism in cancer therapy

Abnormalities in membrane topology and lipid raft integrity, which are caused by deficits in sphingomyelin synthesis [83] and cholesterol uptake [84, 85], directly impair the formation of cytolytic immunological synapses

[34] In April 2007, Aquino gave birth to her second son, James Carlos "Bimby" Aquino Yap Jr., in Makati

However, emerging evidence indicates that mTORC2 also has an important role in autophagy, especially mitophagy (the selective degradation of mitochondria by autophagy), as well as a key positive modulator of longevity [7]