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Bacillus coagulans MTCC 5856 supplementation in the management of diarrhea predominant Irritable Bowel Syndrome: a double blind randomized placebo controlled pilot clinical study

A meta-analysis of 19 randomized clinical trials, including 47,921 subjects with preexisting cardiovascular or renal disease, found that homocysteine lowering through folic acid and other B-vitamin supplementation failed to reduce the incidence of CVD despite significant reductions in plasma homocysteine concentrations (90)

Zhao, B., Nepovimova, E

L.MatsumotoJ

Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group
