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doi: 10.1007/s00125-011-2049-0

No Phase III

Unlike the full-length growth hormone, AOD9604 retains the lipolytic (fat-mobilizing) and anti-lipogenic (fat-inhibiting) properties of hGH, while importantly lacking its proliferative effects (e.g., on glucose levels, IGF-1 production, or cell proliferation)

Our observation that intracellular NA concentrations did not increase following NNMT inhibition extends previous studies that showed NA concentrations were largely unaffected following NNMT knockdown with either adenovirus[39] or anti-sense oligonucleotides (ASOs).[12] It is possible that significant accumulation of NA in adipocytes (and other tissues) is prevented by rapid conversion of NA to NMN and subsequent NAD + synthesis or transport to the extracellular environment.[27] Importantly, NNMT inhibition potentiated the absolute intracellular concentrations of NAD + and SAM, without altering the levels of NA and SAH in the adipocytes
