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AST-treated mice showed enhanced expression of liver cholesterol metabolism genes (LDL receptor, 3-hydroxy-3-methylglutaryl-CoA reductase, and sterol regulatory element-binding protein) and -oxidation-related genes (carnitine palmitoyltransferase-1 and acyl-CoA), but no significant changes in lipogenic gene expression [96]

Long-term application is usually necessary before you see results

LeBar K, Wang Z (2021) Tissue mechanics and physiology: role of collagen accumulation

Saengsin K, Sittiwangkul R, Chattipakorn SC, Chattipakorn N

In addition to iron-catalyzed free radical chain reactions, lipoxygenase (LOXs) can directly oxidize PUFAs and lipid-containing PUFAs in cell membranes, which are considered to have an essential role in ferroptosis [75, 80]