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Therefore, the enhanced expression of VPAC2 could be considered as a mechanism that attempts to counterbalance the VPAC1 dysfunction by upregulating the expression of the functional receptor

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: Selective expression of vasoactive intestinal peptide (VIP) 2 /pituitary adenylate cyclase-activating polypeptide (PACAP) 3 receptors in rabbit and guinea pig gastric and tenia coli smooth muscle cells

Keenan RT, Botson JK, Masri KR, Padnick-Silver L, Lamoreaux B, Albert JA, et al

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