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Description
Adverse reactions of PDE5 inhibitors: an analysis of the World Health Organization pharmacovigilance database

demonstrated that isolated mitochondria enter HeLa cells via macropinocytosis-like fluid-phase uptake, with fewer than 10% escaping endosomes to reach the cytosol and potentially integrate into the host mitochondrial network [29]
Prothrombotic changes, such as erythrocytosis and enhanced platelet reactivity, further contribute to an increased risk of acute cardiovascular events, including myocardial infarction and sudden cardiac death

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