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There are physiological drivers for these things and if those factors are not attended to, failure is the typical result
doi:10.1080/09513590.2018.1540570

These results suggested that PRMT1 regulated fatty acid metabolism by methylating UBE2m at R169

The enzyme, gamma-glutamyl carboxylase, uses a vitamin K cofactor to convert glutamic acid to gamma-carboxyglutamic acid (Gla)
10.1016/j.taap.2022.115931 2 AbuelsaadA
