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There is increased risk in patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (e.g., phenothiazines or general anesthetics) [see PRECAUTIONS
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Another example where GCLC and GS are coordinately regulated but GCLM is unchanged is found in liver-specific retinoid X receptor (RXR) knockout mice (Wu et al., 2004)

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