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doi: 10.1126/scitranslmed.3005893 47

The combination of CGA and caffeine significantly promoted the phosphorylation of AMPK, upregulated hormone-sensitive lipase (HSL) expression, and adipotriglyceride lipase (ATGL), inhibited the expression of transcriptional regulatory factors (SREBP-1C and LXR), and decreased the expression of FAS

For example, T cell activation upregulates a variety of amino acid transporters, including SLC7A5, and deletion of SLC7A5 leads to activation of the mTOR signaling pathway and upregulation of the transcription factor MYC to inhibit T cell proliferation

(For more information about cis-trans isomerism, see Chapter 13 "Unsaturated and Aromatic Hydrocarbons", Section 13.2 "Cis-Trans Isomers (Geometric Isomers)".) Table 17.1 Some Common Fatty Acids Found in Natural Fats Two polyunsaturated fatty acidslinoleic and -linolenic acidsare termed essential fatty acidsA fatty acid that must be obtained from the diet because it cannot be synthesized by the human body