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Based on parents ratings, 52% of children in the methyl B 12 group responded to treatment compared to 26% of children in the placebo group (p=0.086) 2

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Clinical Nutrition, 38(4), 1747-1755

cGAMP binds to stimulator of interferon genes (STING), which further activates interferon regulatory factors 3 and 7 (IRF3, IRF7) that drive type I IFN expression or nuclear factor kappa-light-chain-enhancer of activated B-cell (NF-B) that induces the expression of proinflammatory genes (101104)