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Several drugs tested for CNS disorders and TBI were discarded despite the well-established mitochondrial-enhancing mechanisms because their efficiency is marred due to the presence of the BBB

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influenzae has suggested that carbon utilization occurs primarily via the pentose phosphate pathway under these conditions (Edwards and Palsson, 1999), leading to the production of methylglyoxal and presumably also formaldehyde

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In addition, compared with wild-type mice, ethanol-fed LCN knockout mice had significantly reduced serum transferase, and significantly improved inflammation and steatosis (Moschen et al., 2017)