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The rs694539 variation has shown the significant associations with many noninfectious chronic diseases (NCDs), such as hyperhomocysteinemia [35], nonalcoholic steatohepatitis [36], congenital heart diseases [37], migraine [38], bipolar disorder [39], schizophrenia [40], epilepsy [41], and abdominal aortic diseases [42], and the rs1941404 variation has been reported to be associated with hyperlipidemia [30]

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The recommended daily intake of B12 for female adults is B12 deficiency can cause a range of mild to severe symptoms, such as fatigue, weakness, and confusion

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Goal: to summarize the mechanisms and clinical implications