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The mechanism is confirmed in vitro

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Adoptive transfer of CX3CR1 transduced-T regulatory cells improves homing to the atherosclerotic plaques and dampens atherosclerosis progression

In our study, it was found that ethanol exposure resulted in significant loss of synaptic markers SYP and PSD95, as well as decrease in BDNF levels in the hippocampus of APP/PS1 mice, indicating the accumulated neural damages caused by chronic ethanol exposure at molecular level