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4.4 The PCSK9-LDLR signaling pathway Proprotein convertase subtilisin/kexin type 9 (PCSK9), identified in the early 2000s, is a critical regulator of LDL-cholesterol metabolism due to its ability to degrade LDL receptors (LDLRs) and clear circulating LDL-cholesterol (78, 79)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 95.Carr L.G., Foroud T., Stewart T., Castelluccio P., Edenberg H.J., Li T.K
