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Long-term safety data in humans is lacking

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Well, like insulin resistance, there is something called leptin resistance, where leptin is being released, but the brain isn't "seeing" it

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Downstream analysis, including heatmaps, averaged plots of signals, peak annotation, and GO pathway enrichment analysis, were analyzed using ChIPseeker (V.1.32.1), EnrichedHeatmap (V.1.26.0), and DiffBind (V.3.12.0) (6466)