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Most common side effects like nausea, appetite suppression, and gastrointestinal changes peak during week 23 and resolve significantly within 48 weeks as your body adjusts

assessed the longitudinal association between serum UA level and an incidence of dementia in a study involving 1,598 healthy participants, with available brain MRI data, who were followed for 12 years [117]

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This isn't theoretical

The good news is that the background eventually catches up, but you do have to be prepared to walk around looking, and you can manage the tone, if you will, by managing the dose and the frequency of use