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Furthermore, OMT exhibited notable anti-inflammatory effects through the modulation of TLR4/NF-B, NF-B, MAPKs, and TGF- signaling pathways [12,13,14,15]

However, in primary colon cancer, methylated BNIP3 does not exhibit high expression but rather shows a downregulated trend, and this downregulation is associated with abnormal methylation mediated by DNA methyltransferase 3 (DNMT3) and DNA methyltransferase 1 (DNMT1) (134)

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Additionally, glucokinase is not inhibited by its product G6P, whereas, hexokinase is inhibited by G6P

This principle has significant implications for many areas, including agri-food, where excessive agrochemical residues can result in contamination of water and soil [54]