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Description
Three methylation reactions catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) are required, each using S-adenosylmethionine (SAM) as a methyl group donor
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77 , 78 , 79 , 80 The end result of these changes is the production of rigid, non-deformable erythrocytes that are susceptible to stagnation and destruction by reticuloendothelial macrophages in the spleen and liver
