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Trazodone (TRZ) is a compound with a multi-modal mechanism of action, being a serotonin-2 antagonist/reuptake inhibitor approved in several countries for the treatment of depression with or without anxiety, with a daily dosage range of 150600 mg [12]

Studies have demonstrated that chronic administration of AOD-9604 leads to adaptive changes in adipose tissue, including increased expression of beta-3 adrenergic receptors and enhanced sensitivity to lipolytic signals