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Doctors use B12 shots as a last resort, such as if a supplement isn't working or a B12 deficiency causing severe symptoms

10.1111/j.1398-9995.2007.01389.x [DOI] [PubMed] [Google Scholar] Carmel R

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No significant adverse effects were reported at any dose level tested, including the highest 1mg daily oral dose
In scientific literature, AOD-9604 is studied for investigating
