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Schizophrenia: While there are still a lot of unknowns about schizophrenia, researchers theorize that this psychological disorder is due to a lack of GAD1 in certain regions of the brain.[ref] This lack of GAD1 theoretically leads to an imbalance of too much glutamate (excitation) and too little GABA (inhibition)

ChIP-qPCR assays performed using an anti GFP antibody in HEK293T cells transduced with GFP-ASXL1 1-645 -WT or GFP-ASXL1 1-645 -I574D as well as with GFP-ASXL1 1-591 -WT or GFP-ASXL1 1-591 -I574D showed that both truncated variants of ASXL1 localize to the promoters of ECH1 , POGLUT1 and PGK1 independently of binding of BRD4 (Fig

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