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Inhibition rates exceede 30% at a concentration of 3 mg/mL, demonstrating a strong inhibitory effect on tyrosinase activity (Lee et al., 2023)
The phase 2 and phase 3 clinical trials used the same starting dose for all weight groups
To validate this, rigorous, longterm clinical trials should evaluate these compounds as adjunctive or preventive therapies in earlystage or highrisk populations, assessing biomarkers and clinical outcomes over extended periods [118, 119]
Coxibs and cardiovascular disease
Asian J Androl (2003) 5(3):23142
