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10.1007/s11357-019-00051-9 Geroscience 47 GuanY

Our approach includes: Clinical evaluation before prescribing : We assess your health history, current medications, lab results, and treatment goals before recommending any peptide therapy

Of more than 100 compounds synthesized and tested for TGR inhibition (a more thorough description of compound design will form the basis of a future manuscript), the most promising were selected to be extensively characterized in the in vitro and in vivo studies described below

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Taken together, these comprehensive studies in multiple human and mouse cohorts as well as in lipid-loaded hepatocytes uncover suppressed hepatic AGXT and enhanced LDHA activity leading to oxalate overproduction in both humans and mice with MASH