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Thus the GSH/GSSG ratio is important to normal functioning and is a likely contributor to cellular signaling pathways by activating or inactivating key thiol-containing enzymes

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It affects about 1% of the population (10)

Neh1, as a CNC-bZIP domain, permits Nrf2 to heterodimerize with the small musculoaponeurotic fibrosarcoma (Maf) protein and to form a nuclear complex with the UbcM2 ubiquitin-conjugating enzyme
