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Vitamin B12 Intake from Animal Foods, Biomarkers, and Health Aspects

However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

It's the dose you can administer consistently, store correctly, and sustain long enough to complete a full growth cycle