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GHK-Cu is a naturally occurring copper-binding peptide studied for its role in cellular signaling pathways related to tissue support, extracellular matrix biology, and gene expression
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FOXO4-DRI's disruption of FOXO4-p53 interactions specifically targets these survival mechanisms without affecting normal cell cycle regulation in healthy cells, providing researchers with precision tools for studying senescence biology
Importantly, when researchers blocked TGF- signaling, the pro-bone benefits of MOTS-c were diminished, confirming that the TGF-/Smad pathway is crucial to MOTS-cs action in bone
