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This element regulates spermatogenesis and is mainly mediated by two selenoproteins, which provide an important link with sperm quality and male fertility (115)

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair

Interestingly, GSTO1 polymorphisms and decreased expression have been implicated in several pathological conditions such as Parkinsons and Alzheimers disease 7

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The model was refined by using the real-space refinement module in the Phenix package (V1.17) 42