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Iron is chelated and redox-active in the labile iron pool (LIP) within the cell

Arch Toxicol Suppl 3:95110 Ellouk-Achard S, Levresse V, Martin C, Pham-Huy C, Dutertre-Catella H, Thevenin M, Warnet JM, Claude JR (1995) Ex vivo and in vitro models in acetaminophen hepatotoxicity studies

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doi: 10.3389/fphys.2023.1109587 Received 28 November 2022 Accepted 03 February 2023 Published 14 February 2023 Volume 14 - 2023 Edited by Katsumasa Goto, Toyohashi Sozo University, Japan Reviewed by Gavin Pinniger, University of Western Australia, Australia Dawn A

As an autoimmune disease, the disturbance of the tolerance against self-antigens is the main pathogenic mechanism with a large cellular interplay that involves TFCs, stromal cells and lymphocytes