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2 Mechanisms of hypoxia in the tumor microenvironment 2.1 Development of hypoxia in tumors Hypoxia is a common feature observed in approximately 90% of solid tumors and is widely recognized as a hallmark of cancer ( Figure 3 ) ( Figure 3 Hypoxia in tumors can be broadly categorized into two distinct forms: chronic hypoxia and acute (or cycling) hypoxia ( In contrast, acute hypoxia, also referred to as cycling or intermittent hypoxia, arises due to transient fluctuations in tumor blood flow ((no longer than 24 h))., leading to to oxygen levels below 1% that can be reversed with returned blood flow ( Both chronic and acute hypoxia coexist within tumors and play critical, yet distinct, roles in shaping the tumor biology

In some models, GHK combined with external interventions such as laser exposure or dressing formulations appeared to accelerate wound contraction, vascular development, and epithelialization

It is characterized by significant drug resistance and abnormal energy metabolism

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The Sororin peptide of residues, corresponding to residues 136-158 (either wild-type or the pS145 form) and followed by a Lys-biotin moiety, were synthesized by GL Biochem (Shanghai)