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Trimethylamine N-Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease

The control of cardiovascular risk factors in patients with type 2 diabetes mellitus is essential for improving insulin sensitivity

Indeed, the clinical literature exhibits heterogeneity in design, dosing, duration, and outcome measures, frequent reliance on parent reported scales without uniform blinding, and underpowered samples that hinder strong inference and guideline development ( in vivo studies explicitly exclude female animals to avoid potential confounding effects related to hormonal fluctuations

Brain Res Mol Brain Res 2005