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The flora with increased abundance includes Lactobacillus salivarius , Staphylococcus , Corynebacterium , Bacteroides fragilis , Ruminococcus gnavus , Veillonella parvula , Pseudobutyrivibrio , Escherichia/Shigella , and Streptococcus parasanguinis (201, 203, 204)

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Given that pharmacological alternatives only targeting specific comorbid conditions are limited, and with a significant burden of side effects, further studies utilizing complementary and alternative medicine for the treatment of ASD are justified

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In contrast to the five mammalian sirtuins listed above, yeast SIR2 (Lin et al., 2004) and mammalian mitochondrial SIRT4 were shown to be regulated by the [NAD + ]/[NADH], not by the [NAD + ]