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These shifts from the third or fourth line of care to the earlier stages of cancer care, now including first or second-line settings, are because they are very potent in chemotherapy without significant systemic side effects (219)
In the future, more large-scale and prospective clinical studies are necessary to investigate the effect of active H

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The research gap is financial, not scientific

Tonini, M., Frigo, G., Lecchini, S., DAngelo, L
