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[DOI] [PMC free article] [PubMed] [Google Scholar] 89.Ponnusamy, K., Ramasamy, M., Savarimuthu, I

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The mechanism of action of theses anti-inflammatory effects of MTX are not fully understood [173]

So, yes, stress does cause reflux and stomach ulcers, but chronically stressed/HPA imbalanced patients will not usually make any headway other than short-term relief by taking medications that further reduce stomach acid