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[DOI] [PubMed] [Google Scholar] Erguven M, Yilmaz O, Koc S, Caki S, Ayhan Y, Donmez M, Dolunay G

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Whereas the dose plays a role, the 7-day half-life of T 4 allows physiologic compensation, such as the suppression of T 4 to T 3 conversion, inhibition of endogenous hormone production by negative feedback loops, and downregulation of thyroid hormone receptors
