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Intestinal resection particularly ileum

Neuropsychiatric disorders The decrease in the absorption of vitamin B12 due to metformin may affect the treated patients cognitive function since several studies connected the decline in cognitive functions and some depressive symptoms to low vitamin B12 levels[35]

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Platelet hyperactivity and infertility Platelets are essential for hemostasis, and abnormalities in their activation or hyperaggregability may play a role in the pathophysiology of conditions, including miscarriage and thrombosis with no known cause

Sleep apnea severity decreases as weight drops