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In patients with creatinine clearances between 45 mL/min and 79 mL/min, avoid administration of ibuprofen for 2 days before, the day of, and 2 days following administration of Pemetrexed for Injection

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Medications including metformin, proton pump inhibitors, and H2-receptor antagonists may reduce absorption of B12, potentially prolonging the time to clinical improvement

Malabsorption of Vitamin B12 In The Small Intestine Many stomach and intestinal diseases can affect cobalamin (or vitamin B12) absorption in the small intestine

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