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Abstract Postmenopausal women (PMW) may experience endothelial dysfunction associated with arginine (ARG) deficiency relative to asymmetric dimethylarginine (ADMA) caused by oxidative stress

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Studies have also indicated interactions with opioid pathways DSIP administration has been shown to modulate pain perception and has effects that can be partially blocked by opioid antagonists in some paradigms, suggesting opioidergic involvement in at least some of its actions

Data Availability Statement The datasets used or analysed during the current study are available from the corresponding author on reasonable request.