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According to this, L-leucine, L-isoleucine and L-methionine are better substrates for cellular efflux than influx to the cell (Fotiadis et al., 2013)
The intracellular GPX activity was measured through a cellular glutathione peroxidase assay kit on the basis of the manufacturers instructions
Robey et al
However, the target has been much less explored compared to other targets and deserves the attention of a medicinal chemist for his/her expertise in developing more effective ligands of the transporter as brain targeting agents
