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B., Kumar, G., et al

All information in this article is provided strictly for educational, informational, and research-focused discussion only and should not be interpreted as medical advice or human-use guidance

Cambridge, MA: Academic Press (2023)

Figure 5 A pivotal finding highlighted in this review is the initiation of a multi-faceted pathological cascade in the testicular microenvironment by varicocele-induced venous congestion: elevated local temperature, hypoxia, and metabolic waste accumulation trigger immune cell infiltration and activation, leading to the overproduction of pro-inflammatory cytokines (TNF-, IL-1, IL-6) and ROS

A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta
