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Description
Pickart estimated lethal dose at approximately 22,500 mg for humans (300-fold above effective doses), with animal LD50 studies in mice showing 8 mg per 25g mouse (320 mg/kg, translating to ~22,400 mg for 154 lb human)

Every one found protective effects

10 g/kg or 10 ng/kg (or water (1 mL/rat) (controls)), was given intragastrically at 5 min post-operative time

Oral Pathology & Medicine

Their mechanisms are complementary and the reasoning is coherent, but the combination has never been directly tested