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The gene responsible for classic Bartter syndrome encodes a member of the voltage-gated Cl channels identified as ClC-Kb

These IR-induced mitochondrial defects are evident in both insulin-sensitive tissues (liver, muscle) and in the heart and brain, providing a mechanistic link between metabolic dysfunction and cardiovascularcognitive comorbidity

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All authors have read and agreed to the published version of the manuscript. Ethical Approval: Our institution does not require ethical approval for reporting individual cases or case series

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