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TH signaling has been shown to be important for cone visual pigment expression and pattern formation while an overabundance of TH signaling causes cone degeneration (Ng et al., 2010)
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The INR calculation converts the ratio of a patients PT to that of the mean normal PT accounting for the responsiveness of the specific thromboplastin used in the laboratory conducting the assay of the VKA effect on coagulation factors
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As a result, both kojic acid and hydroquinone are often misused in attempts to bleach the skin
