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PegC was shown to inhibit the phosphorylation of p70S6K and 4EBP1 by decreasing plasma glutamine

Moreover, in elderly humans, low-dose mTORC1 inhibition with RAD001 and BEZ235 reduced infection rates over 12 months, indicating an enhancement of immune function

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Disturbances of normal intracellular (and extracellular) redox balance contribute to susceptibility and/or pathology in many common and complex human diseases