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161 Different from SETDB1, DOT1L gene is located in a frequently deleted region and undergoes somatic mutation that compromises its methyltransferase enzyme activity which leads to reduced H3K79 methylation

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LDN also quiets overactive immune cells in the brain and spinal cord (called microglia) that drive inflammatory responses in conditions related to immune system and persistent pain think of it as finally silencing a car alarm that's been going off for months