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66 Damaged mitochondria induce PINK1 to bind with the translocase of the outer membrane, prompting phosphorylation of Parkin and ubiquitin, labeling damaged mitochondria, and mediating mitophagy
Dizziness or lightheadedness Uncommon, and when reported, usually mild and short-lived
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The metabolism and elimination of NAD+ (and its by-products) could be altered in advanced hepatic or renal dysfunction, and high-dose NAD+ might theoretically affect cardiovascular dynamics, so practitioners generally avoid or closely supervise NAD+ use in such settings
doi: 10.1053/jhep.2001.28510
