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Reduced levels of mitochondrial proteins such as NADH-ubiquinol oxidoreductase (NDUFB8) and voltage-dependent anion channel (VDAC) were observed in the affected white matter of patients with X-ALD (88), suggesting that mitochondrial content or function is impaired in X-ALD

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Finally, different studies utilize differing diagnostic methods

Collectively, these analyses indicate the need for more large-scale, rigorous, and multi-site randomized controlled trials to confirm the effectiveness of oxytocin as a treatment for ASD [110, 111]