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Vitamin D protects against particles-caused lung injury through induction of autophagy in an Nrf2-dependent manner

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis

This can include fried foods, high-fat dairy, and very rich desserts

Lab-tested purity (HPLC test method)

Knockdown of Notch3 can increase the ROS level in lung cancer cells, reduce the expression levels of GPX4 and peroxiredoxin 6 (PRDX6), and then induce lipid peroxidation to trigger cell ferroptosis [178]