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doi: 10.1093/schbul/sbq091

Vitamin B2 (Riboflavin) decreases free radical damage by regenerating Glutathione, which helps boost the immune system

It was shown that HB acts in vitro as a neuroprotective agent against the toxicity of MPTP, which induces a defect in the mitochondrial complex I of dopaminergic neurons (157)

Brain GSH overall did not dier in AD or MCI compared to HC

The treatment effect was then evaluated using Cox proportional hazard regression, with cage assignment included as a random effect and batch as a covariate, using statistical software R (version 3.4.1) with package coxme