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Indeed, 17-AAG (Tanespimycin) and 17-DMAG (Alvespimycin), two synthetic derivates of Geldanamycin antibiotic, used as HSP90 inhibitors, improve physiological parameters in bleomycin-induced pulmonary fibrosis mice model 25,26

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Too much oxygen radicals, aka reactive oxygen species, is damaging to the ETC protein complexes, including complex II

Second, their liquid nature prevents altering the sample surface chemistry by cocrystallizing with the analyte, thus avoiding the formation of the sweet spot effect
